OBJECTIVE: To investigate the clinical efficacy of Weisu granules combined with quadruple therapy in the treatment of Helicobacter pylori（ Hp） positive chronic atrophic gastritis（ CAG）.METHODS: Totally 100 patients with Hp positive CAG admitted into Dongguan People’s Hospital from 2017 to 2019 were extracted to be divided into the control group（ n = 50） and the study group（ n = 50） via the random number table.The control group was treated with quadruple therapy

while the study group received Weisu granules on the basis of the control group.Patients in both groups were treated continuously for 2 weeks.After treatment

the clinical efficacy and eradication rate of Hp of two groups were counted.Serum pepsinogen Ⅰ（ PGⅠ）

pepsinogen Ⅱ（ PGⅡ）

interleukin 1（ IL-1）

interleukin6（ IL-6） and C-reactive protein（ CRP） levels of two groups before and after treatment were observed.The incidence of adverse drug reactions was compared between two groups.RESULTS: The total effective rate of the study group was92.00%（ 46/50）

significantly higher than that of the control group 74.00%（ 37/50）

the difference was statistically significant（ P

<

0.05）.After treatment

the eradication rate of Hp was 70.00%（ 35/50） in the control group and88.00%（ 44/50） in the study group

the eradication rate of Hp in the study group was significantly higher than that in the control group

and the difference was statistically significant（ P

<

0.05）.After treatment

the serum PGⅠ

PGⅠ/PGⅡof two groups were significantly higher than those before treatment

and serum levels of IL-1

IL-6 and CRP were significantly lower than those before treatment.After treatment

the serum PGⅠ

PGⅠ/PGⅡ of the study group were significantly higher than those of the control group

and the serum levels of IL-1

IL-6 and CRP were significantly lower than those of the control group

the differences were statistically significant（ P

<

0.05）.The incidence of adverse drug reactions in the control group and the study group were respectively 8.00%（ 4/50） and 10.00%（ 5/50）

the difference was not statistically significant（χ

2

=0.122

P = 0.727）.CONCLUSIONS: The clinical efficacy of Weisu granules combined with quadruple therapy in the treatment of Hp is significant

which can significantly improve the eradication rate of Hp and the secretion function of gastric mucosa

inhibit the inflammatory response with higher safety.