OBJECTIVE: To probe into the mechanism of Zhishi Xiebai Guizhi decoction in the treatment of pulmonary embolism based on internet pharmacology.METHODS: According to in vivo processes（ absorption

distribution

metabolism and excretion

ADME） properties of the drug components

the main chemical components of trichosanthes

citrus aurantium

citrus aurantium

guizhi and magnolia officinalis were obtained through traditional Chinese medicine systems pharmacology database and analysis platform（ TCMSP）.And the encyclopedia of traditional Chinese medicine（ ETCM） and traditional Chinese medicines integrated database（ TCMID） were used to supply and screen the active components of traditional Chinese medicine.Swiss Target Prediction was adopted to obtain the active ingredient targets.The major targets of pulmonary embolism were obtained from Genecards

online mendelian inheritance in man（ OMIM） and DRUGBANK databases.Protein-protein interaction（ PPI） was analyzed by using String platform

and PPI network was constructed.Metascape platform was used to analyze"drugs-components-targets"and its involved biological processes and pathways.Cytoscape 3.8.0 software was used to construct the network of"Zhishi Xiebai Guizhi decoction-pulmonary embolism-pathway".RESULTS: The core active ingredients of Zhishi Xiebai Guizhi decoction in the treatment of pulmonary embolism were quercetin

luteolin

naringenin and caffeic acid

and the core targets were CYP1 B1 and DRD2.The biological pathways of Zhishi Xiebai Guizhi decoction in the treatment of pulmonary embolism mainly acted on the platelet activation pathway and the Neuroactive ligand-receptor interaction pathway

the main functions were regulating heme binding and protein kinase activity.CONCLUSIONS:This study initially reveals the possible mechanism of active ingredients of Zhishi Xiebai Guizhi decoction in the treatment of pulmonary embolism

and provides clues and evidence for follow-up basic and clinical research.