OBJECTIVE: To investigate and evaluate the occurrence characteristics and rules of adverse drug reaction（ ADR） induced by contrast mediums

and put forward prevention and treatment measures to provide reference for the safe use of contrast mediums in clinic. METHODS: Reports of ADR induced by contrast mediums in imaging examinations in Fuwai Hospital

Chinese Academy of Medical Sciences（ hereinafter referred to as"our hospital"） from2010 to 2018 were retrospectively summarized and analyzed.RESULTS: A total of 1 257 cases of ADR were reported in our hospital from 2010 to 2018

among which 858 cases（ 68. 26%） were reported as ADR induced by contrast mediums

including 5 types of contrast mediums（ non-ionic iodine contrast mediums）. The top 3 contrast mediums ranked by the number of ADR reports were respectively iopromide

iohexol and iodixanol. ADR induced by contrast mediums was mainly allergic reactions

mainly manifested as rash

pruritus

urticaria

facial flushing and mouth and eye swelling.CONCLUSIONS: The safety of contrast mediums in clinical use in our hospital is generally good; close observation should be made during the medication process

and acute or severe allergic reactions should be accurately identified and treated seriously to ensure timely and correct treatment to maximize the safety of patients.