OBJECTIVE: To probe into the characteristics drug-induced thrombocytopenia（ DITP） in the First Affiliated Hospital of University of Science and Technology of China（ hereinafter referred to as "our hospital"）

so as to provide reference for preventing clinical medication risk and improving rational medication.METHODS: Data of the42 cases of DITP patients reported by our hospital from Jan.2018 to Jul.2020 were collected and analyzed by Pareto method in terms of occupation

age and gender

categories of drug

administration route

clinical manifestations and treatment measures.RESULTS: Among the 42 cases of DITP

mainly reported by pharmacists（ 38 cases）; there were21 male and 21 female patients; mainly aged > 18-< 80 years old; 9 categories including 23 kinds of drugs were involved

of which antineoplastics had caused the most DITP cases（ 15 cases）

antineoplastics

antibiotics

antiepileptics and antiplatelet drugs were the main factors; 5 ways of administration were involved

of which intravenous drip was the main factor; the DITP was mostly occurred during 1-14 days after medication（ 26 cases）; 12 cases if DIPT were treated with drug withdrawal without symptomatic treatment

30 cases were given symptomatic treatment

mainly given recombinant human interleukin-11（ rhIL-11） combined with platelet transfusion for treatment.CONCLUSIONS: When clinical application of drugs that may cause DITP

awareness of safe medication should be strengthened

platelet counts should be closely monitored

DITP should be detected as soon as possible and given symptomatic treatment to ensure clinical medication safety.