OBJECTIVE: To probe into the closed-loop management model（ problem discovery-problem analysisproblem solving-result evaluation） to solve drug-related problems（ DRP） in ICU by applying the classification system of Pharmaceutical Care Network Europe（ PCNE） on the pharmaceutical care on ICU patients.METHODS: DRP in ICU patients at the beginning of implementation of classification system of PCNE（ 2018） and one year after implementation（ 2019） in a certain TCM hospital were collected

comparison and analyzed were conducted in terms of the numbers

categories

causes

clinical pharmacist’interventions

outcomes and involved drugs of DRP. RESULTS: Totally 216 patients received pharmaceutical intervention in 2018

and 101 DRP cases were found; 245 patients received pharmaceutical intervention in 2019

and 50 DRP cases were found

which was significantly less than that of 2018.In terms of the categories of DRP

both 2018 and 2019 focused on treatment safety issues; in terms of the causes of DRP

other instructions（ including adverse drug reactions

incompatibility of injections）

inappropriate drug selection（ contraindication） and non-indication medication were the main reasons in 2018

while the non-indication medication

inappropriate drug selection（ not in accordance with the guideline） and other instructions were the main reasons in2019; the comparisons of pharmacists ’ interventions at the physician level

drug level and other levels（ mainly reflected in the intervention at nurse level） between 2018 and 2019 were statistically significant（ P < 0. 01）; the acceptance rate of intervention increased from 90. 10%（ 91/101） in 2018 to 98. 00%（ 49/50） in 2019

and the proportion of all problems solved had increased from 79. 21%（ 80/101） in 2018 to 94. 00%（ 47/50） in 2019

with statistically significant differences（ P < 0. 01）; DRP in ICU had involved many categories of drugs

mainly were antibiotics. CONCLUSIONS: The classification system of PCNE can achieve effective closed-loop management of pharmaceutical care for DRP in ICU

which is helpful to form standardized and normalized pharmaceutical care and provide data basis for clinical pharmacists.