OBJECTIVE: To systematically evaluate the effects of ondansetron hydrochloride injection on adverse drug reactions such as pruritus

shivering

hypotension and bradycardia in patients with cesarean section after anesthesia based on Meta-analysis. METHODS: CBM

CNKI

VIP database

Wanfang database

PubMed and the Cochrane Library were retrieved to collect the randomized controlled trials of ondansetron hydrochloride injection used during cesarean section（ the intervention group was treated with ondansetron hydrochloride injection

while the control group received the equivalent amount of 0. 9% sodium chloride injection）.The retrieval time was from the establishment of the database to Jun. 2019. Meta-analysis was performed by using RevMan 5. 3 software. RESULTS: A total of 23 literature were included

and 2 008 patients were enrolled

including 1 003 patients in the intervention group and 1005 patients in the control group.Meta-analysis results showed that the incidence of pruritus

shivering

hypotension

bradycardia and other adverse drug reactions in patients with cesarean section in the intervention group was significantly lower than that in the control group

with statistically significant difference（ P < 0. 05）. The number of patients with ephedrine during the perioperative period in the intervention group was significantly less than that in the control group

and the difference was statistically significant（ P < 0. 05）. Compared with the control group

the pH of the umbilical artery blood at time of delivery of the fetus in the intervention group was closer to the normal range

and the difference was statistically significant（ P < 0. 05）. There was no significant difference between two groups in the perioperative dosage of ephedrine and Apgar score after delivery of 5 minutes（ P > 0. 05）. CONCLUSIONS: Ondansetron hydrochloride injection can decrease the incidence of pruritus

shivering

hypotension and bradycardia after spinal anesthesia in patients with cesarean section

and reduce the use of ephedrine.