还原性叶酸载体1 G80A基因多态性与急性淋巴细胞白血病患儿使用大剂量甲氨蝶呤不良反应关系的系统评价

张春燕; 黄琳; 任晓蕾; 封宇飞

doi:10.14009/j.issn.1672-2124.2021.02.019

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还原性叶酸载体1 G80A基因多态性与急性淋巴细胞白血病患儿使用大剂量甲氨蝶呤不良反应关系的系统评价

用药评价 | 更新时间：2022-10-08

- 还原性叶酸载体1 G80A基因多态性与急性淋巴细胞白血病患儿使用大剂量甲氨蝶呤不良反应关系的系统评价
- Systematic Review of Correlation between Polymorphism of Reduced Folate Carrier 1 G80A Gene and Adverse Drug Reactions of High-Dose Methotrexate in Children with Acute Lymphoblastic Leukemia
- 中国医院用药评价与分析 2021年21卷第2期页码：204-206
- 作者机构：
  
  北京大学人民医院药剂科
- 作者简介：
- 基金信息：
- DOI：10.14009/j.issn.1672-2124.2021.02.019
  中图分类号： R733.71
- 纸质出版日期：2021，
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[1]张春燕,黄琳,任晓蕾,封宇飞.还原性叶酸载体1 G80A基因多态性与急性淋巴细胞白血病患儿使用大剂量甲氨蝶呤不良反应关系的系统评价[J].中国医院用药评价与分析,2021,21(02):204-206.

ZHANG Chunyan, HUANG Lin, REN Xiaolei, et al. Systematic Review of Correlation between Polymorphism of Reduced Folate Carrier 1 G80A Gene and Adverse Drug Reactions of High-Dose Methotrexate in Children with Acute Lymphoblastic Leukemia[J]. 2021,21(2):204-206.
[1]张春燕,黄琳,任晓蕾,封宇飞.还原性叶酸载体1 G80A基因多态性与急性淋巴细胞白血病患儿使用大剂量甲氨蝶呤不良反应关系的系统评价[J].中国医院用药评价与分析,2021,21(02):204-206. DOI： 10.14009/j.issn.1672-2124.2021.02.019.

ZHANG Chunyan, HUANG Lin, REN Xiaolei, et al. Systematic Review of Correlation between Polymorphism of Reduced Folate Carrier 1 G80A Gene and Adverse Drug Reactions of High-Dose Methotrexate in Children with Acute Lymphoblastic Leukemia[J]. 2021,21(2):204-206. DOI： 10.14009/j.issn.1672-2124.2021.02.019.

摘要

目的:探讨还原叶酸载体1 （reduced folate carrier 1

RFC1） G80A基因多态性与儿童急性淋巴细胞白血病（acute lymphoblastic leukemia

ALL）患者使用大剂量甲氨蝶呤（high dose methotrexate

HDMTX）化疗后不良反应的关系。方法:计算机检索PubMed、Cochrane图书馆和EMBase等数据库

收集RFC1G80A基因多态性与ALL患儿使用HDMTX化疗后发生不良反应的相关性研究

纳入符合标准的临床研究文献

提取有效数据

采用Rev Man 5.3软件对数据进行分析

比较不同RFC1G80A基因型ALL患儿使用HDMTX的不良反应发生情况。结果:共纳入英文文献6篇

Meta分析结果显示

RFC1G80A AA型患儿使用HDMTX的不良反应发生率高于RFC1G80A GA+RFC1G80A GG型患儿

差异具有统计学意义（OR=1.28

95%CI=1.00～1.63

P=0.05）。结论:RFC1G80A基因多态性与HDMTX的不良反应具有统计学意义的相关性。由于本研究纳入的文献数量有限

因此需要谨慎对待评价结果

尚需更多设计更合理、大样本量和多中心的临床对照研究进一步证实。

Abstract

OBJECTIVE: To investigate the correlation between polymorphism of reduced folate carrier 1 G80 A（ RCF1 G80 A） gene and adverse drug reactions of high-dose methotrexate（ HDMTX） in children with acute lymphoblastic leukemia（ ALL）. METHODS: PubMed

the Cochrane Library

EMBase were retrieved to collect the related studies with correlation between RCF1 G80 A gene and adverse drug reactions of HDMTX in children with ALL.Clinical literature that met the standards was included

and effective data were extracted. RevMan 5. 3 software was used to analyze the data and compare the incidence of adverse drug reactions of HDMTX in children with different RFC1 G80 A genotypes of ALL. RESULTS: A total of 6 English literature were included. Meta-analysis results showed that the incidence of adverse drug reactions of HDMTX in children with RFC1 G80 A AA type was higher than that in children with RFC1 G80 A GA+RFC1 G80 A GG type

with statistically significant difference（ OR = 1. 28

95%CI = 1. 00-1. 63

P = 0. 05）.CONCLUSIONS: The polymorphism of RFC1 G80 A gene was significantly correlated with the adverse drug reactions of HDMTX.Due to the limited number of literature included in this study

the evaluation results need to be treated with caution

and more clinical controlled studies with more rational designs

large sample sizes

and multicenters are required for further confirmation.

关键词

还原性叶酸载体基因多态性甲氨蝶呤系统评价

Keywords

Reduced folate carrierPolymorphismMethotrexateSystematic evaluation

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