OBJECTIVE: To systematically evaluate the application effect of simethicone combined with polyethylene glycol electrolyte powder for intestinal preparation before capsule endoscopy. METHODS: Pub Med

EMBase

Ovid

the Cochrane Library

Web of Science

Wanfang database

CNKI

CBM and VIP database were retrieved to collect the randomized controlled trial or clinical controlled study of simethicone combined with polyethylene glycol electrolyte powder for intestinal preparation before capsule endoscopy（ the study group was given simethicone combined with polyethylene glycol electrolyte powder for intestinal cleaning

the control group was treated with polyethylene glycol electrolyte powder for intestinal cleaning）.The retrieval time was from the establishment of the database to Dec.2019.Rev Man 5. 3 software was used for Meta-analysis.RESULTS: Eleven studies were included in this study

including 9 randomized controlled trials and 2 clinical controlled trials.A total of 1 198 patients were enrolled

with 598 patients in the study group and 600 patients in the control group. Meta-analysis results showed that intestinal bubble volume in the study group was less than that in the control group

and the proportion of patients with grade A intestinal bubble volume in the study group was significantly higher than that in the control group

the difference was statistically significant（ OR = 3. 37

95%CI = 1. 96-5. 78

P < 0. 000 01）. The intestinal cleaning in the study group was significantly better than that in the control group

and the proportion of patients with intestinal cleaning level 1 in the study group was significantly higher than that in the control group

the difference was statistically significant（ OR =1. 48

95% CI = 1. 06-2. 08

P = 0. 02）. The gastric passage time of capsule endoscopy in the study group was significantly longer than that in the control group

and the difference was statistically significant（ MD = 3. 02

95%CI =0. 74-5. 30

P = 0. 009）. There was no significant difference in the passage time of small intestine through capsule endoscopy between two groups（ P = 0. 57）. CONCLUSIONS: Simethicone can reduce the amount of bubbles in the intestinal tract and may improve the cleaning of intestinal tract

yet it does not increase the passage time of small intestine through the capsule endoscopy.