OBJECTIVE: To evaluate the efficacy and safety of Reduning injection in the treatment of respiratory infection based on literature analysis

so as to provide evidence-based evidence for clinical practice and decisionmakers. METHODS: PubMed

the Cochrane Library

CNKI

Wanfang and SinoMed database were systematically retrieved to collect the systematic review/Meta-analysis of Reduning injection in the treatment of respiratory infection（ the intervention group was given Reduning injection alone or in combination with other drugs

the control group received placebo or other positive drugs

alone or in combination with other drugs）. According to the inclusion and exclusion criteria

two reviewers screened the literature

extracted the data and evaluated the quality.The evidence was comprehensively combed and analyzed.RESULTS: A total of 8 systematic reviews/Meta-analysis were included.In terms of community-acquired pneumonia

the combined application of Reduning injection on the basis of conventional antibacterial treatment can significantly increase the effective rate and significantly shorten the disappearance time of related clinical symptoms

the differences are statistically significant（ P<0. 05）.The effect of Reduning injection was comparable to that of Xiyanping injection

Yanhuning injection and Tanreqing injection. Compared with ribavirin

Xiyanping injection and Qingkailing injection

Reduning injection might have some advantages in the treatment effectiveness of upper respiratory tract infection. Limited data showed that compared with the control group

the application of Reduning injection did not increase the safety risk.CONCLUSIONS: Combined application of Reduning injection on the basis of conventional treatment can improve the effectiveness of the treatment of respiratory infection

which is basically equivalent to or has certain advantages with ribavirin and other traditional Chinese medicine injections.Due to the limited quality of the included literature

the above results still need to be verified by further high-quality clinical studies.