OBJECTIVE: To investigate the characteristics and drug resistance of Escherichia coli（ E. coli） in the Affiliated Hospital of Chengde Medical College

and to analyze the influencing factors related to the drug resistance of E. coli. METHODS: Bacterial strain identification was conducted on various specimens submitted for clinical examination in the Affiliated Hospital of Chengde Medical College from Aug. 2016 to Aug. 2020

the source of E.coli

distribution of departments and detection of E. coli of extended spectrum β-lactamase（ ESBL） producing were collected

so as to analyze the drug resistance of E. coli to commonly used antibiotics and the factors affecting the resistance of drugs with high resistance rate of E. coli. RESULTS: Totally 389 strains of E. coli were isolated

mainly from urine（ 188 strains

48. 33%）; the mostly was from department of urinary surgery

totally 121 strains（ 31. 11%）; from Aug. 2016 to Aug. 2020

the composition ratio of the number of E. coli strains detected was gradually increasing

and the detection rate of E. coli of ESBL-producing also showed a gradually increasing trend; E.coli had the highest resistance to ampicillin

with the drug resistance rates were respectively 77. 59%（ 45/58）

77. 61%（ 52/67）

79. 27%（ 65/82）

79. 31%（ 69/87） and 81. 05%（ 77/95） on Aug.-Dec. 2016

2017

2018

2019 and Jan.-Aug. 2020. In addition

E. coli also had relatively high resistance to piperacillin and cefazolin; the resistance of E. coli to ampicillin may be related to the application of other antibiotics for ≥15 days and ESBLproducing strains. CONCLUSIONS: From Aug. 2016 to Aug. 2020

the detection rate of E. coli in urology surgery department and urine in the Affiliated Hospital of Chengde Medical College is relatively high

which has high drug resistance. The selection of antibiotics for clinical treatment should be based on the results of drug sensitivity test

so as to avoid the increasing of bacterial resistance rate caused by the abuse of antibiotics.