OBJECTIVE: To systematically evaluate the efficacy

safety and economy of Magnesium isoglycyrrhizinate injection in the treatment of drug-induced liver injury（ DILI）. METHODS: Rapid health technology assessment method（ HTA） was adopted

Pub Med

Cochrane Library

CRD Web

CNKI

Wanfang database were retrieved by two evaluators independently

HTA reports

system review/Meta-analysis and pharmacoeconomic studies about Magnesium isoglycyrrhizinate injection and control drugs in the treatment of DILI were enrolled

literature screen and quality evaluation were conducted according to the inclusion and exclusion criteria

then the conclusion was drawn after data extracting and comprehensive comparison. RESULTS: Totally 2 system review/Meta-analysis and 2 pharmacoeconomic studies were involved. In terms of the effectiveness in the treatment of DILI

the effective rate of magnesium isoglycyrrhizinate injection was better than that of tiopronin injection and diammonium glycyrrhizinate injection

and it had better effect on reducing alanine aminotransferase and aspartate aminotransferase than that of tiopronin injection

diammonium glycyrrhizinate injection

reduced glutathione injection and compound monoammonium glycyrrhizinate S injection

and it had only better effect on reducing total bilirubin and alkaline phosphatase than those of diammonium glycyrrhizinate injection; in terms of safety

the incidence of adverse drug reactions of magnesium isoglycyrrhizinate injection was lower than that of diammonium glycyrrhizinate injection and compound monoammonium glycyrrhizinate S injection; in terms of economy

magnesium isoglycyrrhizinate injection had a certain cost-effectiveness advantage in comparison with diammonium glycyrrhizinate injection and reduced glutathione injection. CONCLUSIONS: Magnesium isoglycyrrhizinate injection has good effect and safety in the treatment of DILI

which has certain economic advantages in my country.