OBJECTIVE: To systematically evaluate the efficacy and safety of Jingling oral liquid combined with methylphenidate hydrochloride in the treatment of children with attention deficit hyperactivity disorder（ ADHD）

so as to provide reference for the treatment of the disease with traditional Chinese medicine. METHODS: The Cochrane Library

PubMed

EMBase

CNKI

Wanfang database and CMB were retrieved to collect the randomized controlled trial（ RCT） of Jingling oral liquid combined with methylphenidate hydrochloride（ study group） and methylphenidate hydrochloride alone（ control group） in the treatment of children with ADHD. The retrieval time was from the establishment of the database to Sept. 2020. After screening the literature according to the inclusion and exclusion criteria

extracting the data and evaluating the methodological quality of the included literature

RevMan 5. 4 software was used for Meta-analysis. RESULTS: A total of 7 RCT were included

including 523 children with ADHD aged from7 to 15 years old

with 265 cases in the study group and 258 cases in the control group. The control group was treated with methylphenidate hydrochloride alone

while the study group received Jingling oral liquid on the basis of the control group. Outcome indicators included conners index of hyperactivity

significant efficiency

total efficiency and adverse drug reactions were analyzed. Meta-analysis results showed that the significant efficiency（ RR = 1. 45

95% CI = 1. 26-1. 72

P < 0. 01）

total efficiency（ RR = 1. 22

95% CI = 1. 13-1. 33

P < 0. 01）

conners index of hyperactivity（ MD =-0. 7

95% CI =-8. 53--5. 44

P < 0. 01） and adverse drug reactions（ RR = 0. 33

95% CI = 0. 17-0. 64

P < 0. 01）were statistically significantly different between two groups

and the study group was higher than the control group.CONCLUSIONS: The efficacy and safety of Jingling oral liquid combined with methylphenidate hydrochloride in the treatment of children with ADHD are higher than that of methylphenidate hydrochloride alone.