OBJECTIVE: To probe into the application of Esomeprazole magnesium enteric-coated tablets combined with Colloidal bismuth pectin capsules and Amoxicillin capsules in elderly patients with functional dyspepsia（ FD） and its effects on nutritional status and insulin-like growth factor-1（ IGF-1） level. METHODS: Totally 104 elderly patients with FD admitted into gastroenterology department of Emergency General Hospital from Jan. 2015 to Jan. 2019 were selected and divided into control group（ 52 cases） and observation group（ 52 cases） via random number table. The control group was treated with Esomeprazole magnesium enteric-coated tablets

while the observation group was given Colloidal bismuth pectin capsules and Amoxicillin capsules based on the control group

evaluation on therapeutic effect was conducted after 15-day treatment

and 6-month follow-up was conducted after treatment. The proximal gastric function parameters

nutritional status

indicators of gastric dynamics

incidence of adverse drug reactions and recurrence were compared between two groups. RESULTS: The proximal gastric functionparameters（ threshold water intake

threshold proximal stomach volume

satiety water intake and satiety proximal stomach volume） and IGF-1 level of observation group after 15-day treatment were significantly higher than those of the control group

with statistically significant differences（ P < 0. 05）; the 4 h and 6 h postprandial gastric emptying rates

hemoglobin

prealbumin and albumin levels of observation group after 15-day treatment were significantly higher than those of the control group

with statistically significant differences（ P < 0. 05）. There were no statistical significance in differences in 1-month recurrence rate and the incidence of adverse drug reactions such as blood pressure fluctuations

liver and kidney abnormalities

dizziness and sleepiness between two groups（ P > 0. 05）; the recurrence rates at 3 and 6 month after treatment in observation group were significantly lower than those of the control group

with statistically significant differences（ P < 0. 05）. CONCLUSIONS: The application of Esomeprazole magnesium enteric-coated tablets combined with Colloidal bismuth pectin capsules and Amoxicillin capsules for elderly patients with functional dyspepsia can improve the gastric function and gastric dynamics

which is conducive to improve the nutritional status and reduce the recurrence rate after treatment

without increasing adverse drug reactions.