OBJECTIVE: To compare the efficacy of different dosing frequency of cefoperazone sodium and sulbactam sodium in patients with acute exacerbation of chronic obstructive pulmonary disease and its effects on pathogen clearance rate

so as to provide guidance for the rational use of antibiotics for patients with chronic obstructive pulmonary disease in clinic. METHODS: Totally 120 patients with acute exacerbation of chronic obstructive pulmonary disease admitted into the Second Affiliated Hospital of Xingtai Medical College from Jan. 2018 to Jan. 2019 were extracted to be divided into the study group（ n = 60） and the control group（ n = 60） via the random number table.The study group was treated with cefoperazone sodium and sulbactam sodium 3. 0 g once every 8 hours

while the control group received cefoperazone sodium and sulbactam sodium 3. 0 g once every 12 hours. Both groups were treated for 10 d.The clinical efficacy

forced expiratory volume in one second（ FEV1）

FEV1/FVC

blood oxygen saturation

arterial partial pressure of oxygen and sleep score

recovery time of clinical symptoms

recovery time of laboratory examination

serum bactericidal activity（ SBA） and pathogen clearance rate of two groups were observed. RESULTS: The total clinical effective rate was 98. 33%（ 59/60） in the study group

significantly higher than 90. 00%（ 54/60） in the control group

with statistically significant difference（ P < 0. 05）. FEV1

FEV1/FCV

blood oxygen saturation

arterial partial pressure of oxygen and sleep scores of the study group were significantly better than those of the control group

and the recovery time of fever

cough

C-reactive protein and neutrophil was significantly shorter than that of the control group

SBA at peak and valley time was significantly higher than that of the control group

the difference was statistically significant（ P < 0. 05）. The pathogen clearance rate in the study group was 88. 46%（ 46/52）

significantly higher than66. 00%（ 33/50） in the control group

with statistically significant difference（ P < 0. 05）. CONCLUSIONS:Treatment with cefoperazone sodium and sulbactam sodium every 8 hours can significantly improve the clinical efficacy of patients with chronic obstructive pulmonary disease

and effectively improve lung function and pathogen clearance

the SBA of Pseudomonas aeruginosa

Klebsiella pneumoniae

Escherichia coli and Acinetobacter baumannii is higher than treatment with cefoperazone sodium and sulbactam sodium every 12 hours.