OBJECTIVE: To probe into the effects of recombinant human brain natriuretic peptide combined with nicorandil on cardiac function and serum nitric oxide（ NO）

endothelin（ ET-1） levels in patients with ischemic heart failure. METHODS: Totally 100 patients with ischemic heart failure admitted into Xingtai Third Hospital from May2019 to Mar. 2020 were extracted to be divided into the control group（ n = 50） and the study group（ n = 50） via the random number table. The control group was treated with conventional therapy + recombinant human brain natriuretic peptide

while the study group received nicorandil on the basis of the control group. The cardiac function of two groups was observed after treatment of 4 weeks

and the changes of serum NO and ET-1 levels and the occurrence of adverse drug reactions were monitored. RESULTS: The cardiac function of both groups was significantly improved

yet the total effective rate of the study group was 96%（ 48/50）

significantly higher than that in the control group（ 88%

44/50）

with statistically significant difference（ P < 0. 05）. After treatment

the left ventricular end-systolic and end-diastolic diameters in the study group were significantly lower than those in the control group

while the left ventricular ejection fraction was significantly higher than that in the control group

with statistically significant differences（ P < 0. 05）.Compared with the control group

the serum NO in the study group increased significantly after treatment

while the serum ET-1 decreased significantly

with statistically significant differences（ P < 0. 05）. The incidences of adverse drug reactions in the study group and the control group were respectively 10%（ 5/50） and 12%（ 6/50）

with no statistically significant difference（ P > 0. 05）. CONCLUSIONS: The efficacy of recombinant human brain natriuretic peptide combined with nicorandil in the treatment of schemic heart failure is significant

which can improve the cardiac function in multiple ways without increasing the incidence of adverse drug reactions.