OBJECTIVE: To compare the clinical efficacy and economic effects of Atorvastatin calcium tablets generics（ Ale） and original drugs（ Lipitor） in the treatment of hyperlipidemia. METHODS: Totally 150 patients with hyperlipidemia admitted into Qianjiang Central Hospital of Chongqing from Jan. 2017 to Dec. 2019 were extracted to be divided into the observation group and the control group via the random number table

with 75 cases in each group. The control group was given Atorvastatin calcium tablets original drugs（ Lipitor） 20 mg/d

while the observation group received Atorvastatin calcium tablets generics（ Ale） 20 mg/d. Both groups were treated for 24 weeks. Blood lipids[triglycerides（ TG）

total cholesterol（ TC）

low density lipoprotein cholesterol（ LDL-C） and high density lipoprotein cholesterol（ HDL-C） levels]of two groups were detected. The clinical efficacy and safety of drug treatment between two groups were compared

and the drug economy was evaluated. RESULTS: Compared with before treatment

the plasma TC

TG and LDL-C levels of two groups decreased significantly after treatment

while the plasma HDL-C levels increased significantly

with statistically significant differences（ P < 0. 05）. After treatment

there was no significant difference in TG

TC

LDL-C and HDL-C levels between two groups（ P > 0. 05）. The total effective rates of lipid regulation in the observation group and control group were 92. 00%（ 69/75） and 94. 67%（ 71/75）

respectively. The incidence of adverse drug reactions in the observation group and the control group were respectively 10. 67%（ 8/75）and 12. 00%（ 9/75）

the difference was not statistically significant（ P > 0. 05）. The total costs of the observation group and the control group were respectively 92. 40 and 1 026. 48 yuan

and the cost-effectiveness ratios were respectively 1. 01 and 10. 84. Taking observe group as the reference

the incremental cost-effectiveness ratio was positive number

indicating that the cost of the control group（ Lipitor group） decreased

and its drug efficacy also decreased

therefore

the observation group（ Ale group） was the most economical. Sensitivity analysis（ 10% reduction in drug costs） results were consistent with the results of cost-effectiveness analysis. CONCLUSIONS: Both Atorvastatin calcium tablets generics（ Ale） and primordia（ Lipitor） are effective in the treatment of hyperlipidemia with higher safety

yet generics（ Ale） have more pharmacoeconomic advantages.