OBJECTIVE: To investigate the clinical efficacy of acupoint application of Tingli Shengmai Wuling powder combined with routine western medicine in the treatment of chronic heart failure. METHODS: Totally 120 patients with chronic heart failure admitted into Shijiazhuang Traditional Chinese Medicine Hospital from Jan. 2016 to Feb. 2019 were extracted to be divided into the control group（ routine western medicine） and the research group（ acupoint application of Tingli Shengmai Wuling powder on the basis of the control group） via the random number table

with 60 cases in each group. Differences of clinical efficacy

cardiac function

serum high sensitivity C-reactive protein（ hs-CRP）

serum brain natriuretic peptide（ BNP）

serum interleukin 6（ IL-6）

serum tumor necrosis factor α（ TNF-α） and adverse drug reactions of two groups were compared. RESULTS: After treatment of 2 weeks

the total effective rate of the study group was 88. 33%（ 53/60）

significantly higher than 70. 00%（ 42/60） of the control group

the difference was statistically significant（ P < 0. 05）. Compared with before treatment

after treatment of 2 weeks

the left ventricular end-systolic diameter（ LVESD）

left ventricular end-diastolic diameter（ LVEDD）

hypersensitive C-reactive protein（ hs-CRP）

B-type natriuretic peptide（ BNP）

interleukin 6（ IL-6） and tumor necrosis factor α（ TNF-α） decreased significantly

the left ventricular ejection fraction（ LVEF） and 6 min walking distance increased significantly

differences were statistically significant（ P < 0. 05）. After treatment of 2 weeks

the levels of LVESD

LVEDD

hs-CRP

BNP

IL-6 and TNF-α in the study group were significantly lower than those in the control group at the same period

while the levels of LVEF were significantly higher than those in the control group at the same period

and the 6 min walking distance was significantly longer than that in the control group at the same period

with statistically significant differences（ P < 0. 05）. The incidence of adverse drug reactions in the control group and the study group were respectively 13. 33%（ 8/60） and 15. 00%（ 9/60）

the difference was not statistically significant（ P > 0. 05）. CONCLUSIONS: The efficacy of acupoint application of Tingli Shengmai Wuling powder combined with routine western medicine in the treatment of chronic heart failure is significant

which can effectively improve the cardiac function of patients and serum hs-CRP

BNP

IL-6 and TNF-α levels without increasing the incidence of adverse drug reactions.