OBJECTIVE:To evaluate the application rationality of cefixime in outpatient and emergency department of a grade Ⅲ

level A hospital（hereinafter referred to as " the hospital"）.METHODS:According to cefixime instructions and Guidelines for Clinical Application of Antibiotics（2015 Edition）

Management Standards for Hospital Prescription Review（Trial） and related literature

the evaluation indicators

evaluation content and evaluation criteria for the rational applic:ation of cefixime were established.Application rationality of cefoxime in 507 prescriptions with cefixime in outpatient and emergency department of the hospital from Oct.to Nov.2019 was evaluated by weighted preference by similarity to an Ideal solution（TOPSIS）.RESULTS:Of the 507 prescriptions with cefixime

there were 127 prescriptions（25.0%） with a degree of closeness（C-） of 1 to the optimal plan

there were5 prescriptions（1.0%） within the C

i

range of 0.8-

<

0.9

267 prescriptions（52.7%） within the C

i

range of 0.7-

<

0.8

96 prescriptions（18.9%） within the C

i

range of 0.6-

<

0.7

and 12 prescriptions（2.4%） within the C

i

range of0.5-

<

0.6.CONCLUSIONS:The application of cefixime in the outpatient and emergency departments of this hospital is rational

but the rational application of cefixime in the authority of the prescribing clinicians and indications is still needed.