OBJECTIVE:To systematically evaluate the efficacy and safety of recombinant human granulocytemacrophage colony stimulating factor（rhGM-CSF） in the treatment of burn wounds based on Meta-analysis

so as to provide relevant evidence-based medicine for clinical medication.METHODS:CNKI

CBM

VIP

Wanfang database

PubMed and the Cochrane Library were retrieved to collect randomized controlled trial of rhGM-CSF in the treatment of burn wounds（research group） and routine treatment of burn wounds（control group）.After the methodological quality of the included studies was evaluated and the data were extracted

Meta-analysis was performed by using RevMan 5.3 software.RESULTS:Totally 8 literature were collected

including 1 101 patients（with 551 cases in the research group and 550 cases in the control group）.Meta-analysis results showed that the differences of wound healing rate at 6 to7 d（MD=10.32

95%CI=6.72-13.92

P<0.000 01）

the wound healing rate at 12 to 14 d（

D=18.55

95%CI=15.50-21.60

P<0.000 01）

the wound healing rate at 21 d（MD=18.96

95%CI=18.00-19.92

P<0.000 01）

the wound healing time（MD=-5.57

95% CI=-6.35--4.78

P<0.000 01） and the total effective rate（RR=1.11

95%CI=1.05-1.17

P=0.000 1） in two groups were statistically significant

and the wound healing of the research group was significantly better than that of the control group.There was no statistically significant difference in the adverse drug reactions of wound healing between two groups（RR=0.99

95% CI=0.98-1.01

P=0.31）.CONCLUSIONS:rhGM-CSF has significant efficacy on burn wounds without severe adverse drug reactions

yet this conclusion needs to be confirmed by more high-quality and large sample studies.