OBJECTIVE:To systematically evaluate the clinical effects of osteopeptide injection in the adjuvant treatment of postoperative healing of limb fracture based on Meta-analysis

so as to guide the clinical practice more effectively.METHODS:CNKI

VIP

SinoMed

Wanfang database

ChiCTR

PubMed

EMBase

the Cochrane Library and other databases were retrieved to collect the randomized controlled trial of osteopeptide injection in the adjuvant treatment of postoperative limb fracture（the intervention measures of the observation group were osteopeptide injection

while the control group did not use osteopeptide injection

both groups could be treated with drugs or other treatments at the same time）.The retrieval time was from establishment of the database to Mar.2020.Methodological quality evaluation of the randomized controlled clinical trial was carried out according to the improved Jadad quality scoring method

and Meta-analysis was performed by using Stata 15.0 software.RESULTS:A total of 5 clinical randomized controlled trials were collected

including 444 patients

there were 222 patients in the observation group and 222 patients in the control group.Meta-analysis results showed that the improvement rate of osteopeptide injection in the adjuvant treatment of postoperative limb fractures in the observation group was significantly better than that in the control group

with statistically significant difference（OR=2.62

95% CI=1.84-3.73

P <0.01）.Two articles reported adverse drug reactions in the observation group

which were cured after simple symptomatic treatment without obvious sequelae symptoms.CONCLUSIONS:Osteopeptide injection can improve the improvement rate and has higher safety in the treatment of postoperative limb fractures.It is recommended that osteopeptide injection should be used in clinic according to the actual situation of patients

and adverse drug reactions should be observed.Currently

only relevant Chinese data are available

and the number of valuable papers is limited.The results of this study still need to be verified by high-quality clinical studies.