OBJECTIVE:To probe into the clinical efficacy of piedomodec combined with chlorretatin in the treatment of allergic rhinitis and its effects on serum eosinophils（EOS） and granulocyte-macrophage colony stimulating factor（GM-CSF）.METHODS:Totally 120 patients with allergic rhinitis admitted into People ’s Hospital of Beijing Daxing District from Jan.2018 to Jun.2019 were extracted to be divided into the control group and the observation group via the random number table

with 60 cases in each group.Patients in the control group were given loratadine orally

while the observation group received Pidomod tablets orally on the basis of the control group.The clinical effects

remission of symptoms and signs

quality of life score and adverse drug reactions

changes of serum levels of interleukin-4（IL-4）

interleukin-5（IL-5）

interleukin-12（IL-12）

tumor necrosis factor（TNF-α）

EOS and GM-CSF before treatment and after treatment of 4 weeks of two groups were compared.RESULTS:After treatment

the total effective rate of the observation group was 88.33%（53/60）

significantly higher than that of the control group73.33%（44/60）

the difference was statistically significant（χ

2

=4.36

P=0.04）.After treatment

nasal symptoms and eye symptoms in both groups were significantly relieved compared with those before treatment

and scores of nasal itching

nasal congestion

sneezing

runny nose

tearing and eye itching in the observation group were significantly lower than those in the control group;after treatment

the scores of all dimensions of quality of life scale of rhinoconjunctivitis in two groups were significantly improved compared with those before treatment

and the scores of daily life

sleep

practical problems

non-nasal（eye） symptoms

nasal symptoms

eye symptoms and emotions in the observation group were significantly lower than those in the control group

with statistically significant differences（P

<

0.05）.After treatment of 4 weeks

the serum levels of IL-4

IL-5

EOS and GM-CSF in both groups were significantly lower than those before treatment

and the observation group was significantly lower than the control group;the levels of IL-12 and TNF-α in both groups were significantly higher than those before treatment

and the observation group was significantly higher than the control group（P

<

0.05）.The incidence of adverse drug reactions in the observation group and the control group was respectively 23.33%（14/60） and 26.67%（16/60）

with no statistically significant difference（χ

2

=1.44

P=0.23）.CONCLUSIONS:Piedomodec combined with chlorretatin orally can effectively improve the clinical efficacy and quality of life in patients with allergic rhinitis

regulate the imbalance of Thl/Th2 cytokines

reduce the levels of serum inflammatory factors

EOS and GM-CSF

and the patients are well tolerated.