OBJECTIVE:To explore the efficacy of compound α-ketoacid tablets combined with levocarnitine injection in the treatment of chronic renal failure and its effects on serum leptin and blood urea nitrogen（BUN） levels.METHODS:Totally 110 patients with chronic renal failure admitted into Liaoyang Hospital of Traditional Chinese Medicine from Sept.2018 to Sept.2019 were extracted to be randomly divided into the combined group and the control group

with 55 cases in each group.The control group was treated with levocarnitine injection

while the combined group was given compound α-ketoacid tablets on the basis of the control group.The serum creatine（SCR）

BUN

Cystatin C（CysC）

serum leptin and inflammatory indicators of two groups were observed

and the recovery time of renal function

clinical efficacy and adverse drug reactions were compared between two groups.RESULTS:The levels of BUN

SCr

CysC and serum leptin in two groups after treatment were significantly lower than those before treatment

and the combined group was significantly lower than the control group

the differences were statistically significant（P<0.05）.The recovery time of renal function in the combined group was significantly shorter than that in the control group

and the difference was statistically significant（P<0.05）.The inflammatory indicators of two groups after treatment were significantly lower than those before treatment

and the combined group was significantly lower than the control group

with statistically significant differences（P<0.05）.After treatment

the total effective rate in the combined group was 94.55%（52/55）

significantly higher than 78.18%（43/55） in the control group

and the difference was statistically significant（P<0.05）.The total incidence of adverse drug reactions in the combined group and the control group was 7.27%（4/55） and 10.91%（6/55）

respectively

with no statistically significant difference（P>0.05）.CONCLUSIONS:The efficacy of compound α-ketoacid tablets combined with levocarnitine injection in the treatment of chronic renal failure is significant

which can effectively alleviate the patients’inflammatory state and promote the recovery of renal function.