OBJECTIVE:To probe into the clinical efficacy of Jubei mixture combined with budesonide in the treatment of bronchial asthma in children.METHODS:Totally 116 children with bronchial asthma admitted into the Third People ’s Hospital of Yancheng from Jan.2018 to Jan.2020 were selected and divided into control group and observation group via random number table

with 58 cases in each group.The control group was treated with budesonide

while the observation group was given Jubei mixture combined with budesonide

both groups were continuously treated for 14 days.Evaluation on clinical efficacy was conducted after treatment

remission times of cough

gasp

lung wheezing and lung moist rales

forced expiratory volume in one second（FEV

1

）

forced vital capacity（FVC）

the proportion of FEV

1

accounted for its predicted value（FEV

1

%）

serum C-reactive protein（CRP）

interleukin 4（IL-4）

interleukin 10（IL-10） levels before and after treatment

and incidence of adverse drug reactions of the two groups during treatment were observed.RESULTS:The total effective rate of observation group was96.55%（56/58）

which was significantly higher than that of the control group（86.21%

50/58）

with statistically significant difference（P

<

0.05）.The remission times of cough

gasp

lung wheezing and lung moist rales of observation group were significantly shorter than those of the control group

with statistically significant differences（P

<

0.05）.Compared with before treatment

the FEV

1

FVC and FEV

1

% levels of both groups had been significantly increased

and those of the observation group were significantly higher than the control group

with statistically significant differences（P

<

0.05）.Compared with before treatment

after treatment

the serum CRP and IL-4 levels of both groups had been significantly decreased

while the serum IL-10 levels were significantly increased;the serum CRP and IL-4 levels of observation group were significantly lower than those of the control group

while the serum IL-10 level of observation group was significantly higher than those of the control group

with statistically significant differences（P

<

0.05）.The incidences of adverse drug reactions of observation group and control group were respectively 10.34%（6/58） and 6.90%（4/58）

the difference had no statistical significance（P

>

0.05）.CONCLUSIONS:The efficacy of Jubei mixture combined with budesonide in the treatment of bronchial asthma in children is remarkable

which can significantly shorten the remission time of clinical symptoms

improve pulmonary function and relieve inflammatory reaction

with good safety.