OBJECTIVE:To probe into the potential mechanism and feasibility of Shenling Baizhu powder in the treatment of Qi-deficiency of lung and spleen of COVID-19 in recovery phase.METHODS:Use the Chinese medicine database to screen the active ingredients of Shenling Baizhu powder and predict the targets;use Cytoscape to construct and analyze the network;to extract important targets through the protein interaction network among targets;to perform biological function and pathway enrichment analyses on important targets;and to conduct molecular docking experiment through iGEMDOCK.RESULTS:Totally 127 kinds of active ingredients were contained in Shenling Baizhu powder

193 targets were predicted

and the core ingredients were dihydroquercetin

kaempferol and luteolin.26 important targets were enriched in neuro-endocrine related functions including immune-inflammatory response（pathways of interleukin 17

B cells and tumor necrosis factor）

regulation of angiotensin on circulatory system

and adrenergic.Of which 5 core ingredients had the potential to bind to COVID-19 targets.CONCLUSIONS:Shenling Baizhu powder may act on the immune-inflammatory response

circulation and neuro-endocrine related signal pathways

combined with regulating the intestinal flora

so as to treat the Qi-deficiency of lung and spleen of COVID-19 in recovery phase.