OBJECTIVE:To probe into the effects of ticagrelor and clopidogrel in the prevention of minor myocardial injury（MMI） and major adverse clinical events（MACE） in patients undergoing percutaneous coronary intervention（PCI）.METHODS:Totally 372 patients undergoing PCI in the First Affiliated Hospital of Xi’an Jiaotong University from 2018 to 2019 were extracted to be divided into the clopidogrel group and the ticagrelor group via the random number table

with 186 cases in each group.Patients in the clopidogrel group and the ticagrelor group were respectively treated with clopidogrel and ticagrelor before surgery.Cardiac troponin Ⅰ（cTn Ⅰ） and creatine kinase isoenzyme（CK-MB） were detected and compared between two groups at baseline and 12 h after surgery.The clinical prognostic indicators of two groups were compared

including the incidence of MMI

MACE（death

PCI related myocardial infarction

stroke and transient ischemic attack） and length of stay.According to the occurrence of MMI

patients were divided into the MMI group and the non-MMI group.The baseline clinical data of patients in the MMI group and the non-MMI group were compared

including demography

complication

laboratory indicators

drug use

coronary stent implantation location

surgical indicators and lesion types.Multivariate Logistic regression analysis was used to evaluate the independent predictors of MMI.RESULTS:Changes from baseline in the ticagrelor group at 12 h after surgery △cTn I（t=17.281

P

<

0.001） and △CK-MB（t=14.604

P

<

0.001） were significantly lower than those in the clopidogrel group.The incidence of MMI in the ticagrelor group was significantly lower than that in the clopidogrel group [18.8%（35/186） vs.32.8%（61/186）

χ

2

=9.491

P=0.002].The incidence of MACE（χ

2

-10.735

P=0.001） and myocardial infarction（X2=8.278

P=0.004） in the ticagrelor group was significantly lower than that in the clopidogrel group

with statistically significant differences.Multivariate analysis showed that clopidogrel treatment（OiR=2.678

95%CI=1.147-6.239

P=0.028）

saphenous vein implantation intervention（OR=3.682

95%CI=1.177-11.521

P=0.015） and type C lesions（OR=1.246

95% CI=1.080-1.525

P=0.041） were independent predictors of MMI.CONCLUSIONS:Ticagrelor is more effective than clopidogrel in reducing the incidence of MMI and MACE in patients undergoing PCI.