OBJECTIVE: To probe into the management mode of clinical application of antibiotics in People’s Hospital of Ningxia Hui Autonomous Region（ hereinafter referred to as "our hospital"） with the help of informationbased system. METHODS: The clinical application of antibiotics in outpatient and emergency department and inpatient wards of our hospital from 2017 to 2019 were selected as the research object. Retrospective analysis was conducted on clinical application rate

defined daily dose system（ DDDs）

consumption sum

microbiological test rate and review of rational drug application. And the management mode was comprehensively assessed. RESULTS: Compared with 2017

in 2018 and 2019

the application rate of antibiotics in outpatient

emergency and inpatient department in our hospital decreased significantly

the application rate of intravenous infusion in outpatient and emergency department decreased significantly

the preventive application rate of antibiotics in inpatients with type I incision surgery decreased significantly

the single application rate of antibiotics in inpatients decreased significantly and the combined application rate decreased significantly

the application rate of non-restricted-use antibiotics in inpatients increased significantly

and the application rate of restricted-use antibiotics decreased significantly

moreover

the above indicators in 2019 were significantly better than those in 2018

and the differences were statistically significant（ P < 0. 01）. Compared with 2017

in 2018 and 2019

the proportion of the consumption sum of antibiotics for outpatients and inpatients to the total consumption sum of drugs decreased significantly

the proportion of the consumption sum of non-restricted-use antibiotics to the total consumption sum of drugs increased significantly

the proportion of the consumption sum of restricted-use and special-use antibiotics in the consumption sum of drugs decreased significantly

the differences were statistically significant（ P < 0. 05 or P < 0. 01）. Compared with 2017

the microbiological test rate increased significantly

and the microbiological test rate in 2019 was significantly higher than that in 2018

with statistically significant differences（ P < 0. 01）. Compared with 2017

the proportion of irrational prescriptions/medical orders in outpatient and emergency prescription review and inpatient medical order review decreased significantly

and the difference was statistically significant（ P < 0. 05 or P < 0. 01）. Over the past 3 years

the DDDs of antibiotics changed.CONCLUSIONS: The establishment of objective evaluation system for antibiotics management through big data makes the clinical application of antibiotics more rational and has guiding significance for the clinical application and management of antibiotics in the hospital.