1554例住院抑郁障碍患者抗抑郁药应用分析

果伟; 刘珊珊; 庄红艳

doi:10.14009/j.issn.1672-2124.2020.11.022

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1554例住院抑郁障碍患者抗抑郁药应用分析

用药分析 | 更新时间：2022-10-08

- 1554例住院抑郁障碍患者抗抑郁药应用分析
- Application of Antidepressant Drugs in 1554 Inpatients with Depressive Disorder
- 中国医院用药评价与分析 2020年20卷第11期页码：1370-1373
- 作者机构：
  
  1. 首都医科大学附属北京安定医院药事部国家精神心理疾病临床医学研究中心精神疾病诊断与治疗北京市重点实验室
  2. 首都医科大学人脑保护高精尖创新中心
- 作者简介：
- 基金信息：
  
  国家自然基金面上项目（No.81873398）;首都卫生发展科研专项项目（No．首发2018-4-2124）;首都卫生发展科研专项重点攻关项目（No．首发2018-1-2122）;北京中医药科技发展资金项目（No.JJ2018-42）;北京市属医院科研培育计划（No.PZ2020031）
- DOI：10.14009/j.issn.1672-2124.2020.11.022
  中图分类号： R95
- 纸质出版日期：2020，
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[1]果伟,刘珊珊,庄红艳.1554例住院抑郁障碍患者抗抑郁药应用分析[J].中国医院用药评价与分析,2020,20(11):1370-1373.

GUO Wei, LIU Shanshan, ZHUANG Hongyan. Application of Antidepressant Drugs in 1554 Inpatients with Depressive Disorder[J]. 2020,20(11):1370-1373.
[1]果伟,刘珊珊,庄红艳.1554例住院抑郁障碍患者抗抑郁药应用分析[J].中国医院用药评价与分析,2020,20(11):1370-1373. DOI： 10.14009/j.issn.1672-2124.2020.11.022.

GUO Wei, LIU Shanshan, ZHUANG Hongyan. Application of Antidepressant Drugs in 1554 Inpatients with Depressive Disorder[J]. 2020,20(11):1370-1373. DOI： 10.14009/j.issn.1672-2124.2020.11.022.

摘要

目的:调查首都医科大学附属北京安定医院（以下简称"我院"）住院抑郁障碍患者抗抑郁药使用现状

为临床合理使用抗抑郁药提供依据。方法:以2019年我院住院抑郁障碍患者抗抑郁药医嘱为依据

调查并分析患者的人口学资料、不同年龄患者抗抑郁药使用种类、单一抗抑郁药使用的种类及频率、不同年龄及性别患者抗抑郁药剂量等

探讨住院抑郁障碍患者抗抑郁药的使用特点。结果:共有1 554例患者入组

使用频率排序居前5位的抗抑郁药依次为盐酸舍曲林、草酸艾司西酞普兰、盐酸文拉法辛、盐酸度洛西汀和盐酸帕罗西汀;单一抗抑郁药中

盐酸舍曲林、草酸艾司西酞普兰和盐酸文拉法辛的使用频率排序居前3位。青少年患者使用盐酸舍曲林和草酸艾司西酞普兰的剂量显著低于中老年患者

男性患者使用盐酸度洛西汀的剂量显著高于女性患者

上述差异均有统计学意义（P均<0.05）。结论:住院抑郁障碍患者使用的抗抑郁药主要为新型抗抑郁药

精神专科医院抗抑郁药的使用以盐酸舍曲林、草酸艾司西酞普兰以及盐酸文拉法辛为主。青少年抑郁障碍患者使用盐酸舍曲林和草酸艾司西酞普兰的剂量普遍低于中老年患者

男性患者使用盐酸度洛西汀的剂量高于女性患者。

Abstract

OBJECTIVE: To investigate the application status of antidepressant drugs in inpatients with depressive disorder in Beijing Anding Hospital

Capital Medical University（ hereinafter referred to as "our hospital"）

so as to provide evidence for the rational application of antidepressant drugs in clinical practice. METHODS: Based on the medical orders of antidepressant drugs in inpatients with depressive disorder in our hospital in 2019

the demographic data of patients

the categories of antidepressant drugs used by patients of different age

the categories and frequencies of single antidepressant drugs

and the dose of patients of different age and gender were investigated and analyzed.Characteristics of antidepressant drugs applied in inpatients with depressive disorder were explored. RESULTS: A total of 1 554 patients were enrolled

the top 5 antidepressant drugs ranked by application frequency were respectively sertraline hydrochloride

escitalopram oxalate

venlafaxine hydrochloride

duloxetine hydrochloride and paroxetine hydrochloride. Among single antidepressant drugs

sertraline hydrochloride

escitalopram oxalate and venlafaxine hydrochloride ranked the top 3 in application frequency. Doses of sertraline hydrochloride and escitalopram oxalate were significantly lower in the adolescent group than in the middle-aged and elderly group

and doses of duloxetine hydrochloride were significantly higher in the male group than in the female group

with statistically significant difference（ P < 0. 05）. CONCLUSIONS: The application of antidepressant drugs in inpatients with depressive disorder is mainly new types of antidepressant drugs

and the application of antidepressants in psychiatric hospitals was mainly sertraline hydrochloride

escitalopram oxalate and venlafaxine hydrochloride. Doses of sertraline hydrochloride and escitalopram oxalate are generally lower in adolescents with depressive disorder than in middle-aged and elderly patients

and doses of duloxetine hydrochloride were higher in males than in females.

关键词

抗抑郁药抑郁障碍住院患者精神专科医院

Keywords

Antidepressant drugsDepressive disorderInpatientsPsychiatric hospital

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