OBJECTIVE: To systematically evaluate the efficacy and safety of three kinds of proton pump inhibitors in the treatment of stress ulcer bleeding. METHODS: Databases were electronically searched for randomized controlled trials of esomeprazole

pantoprazole and omeprazole in the treatment of stress ulcer bleeding（ any two of esomeprazole

pantoprazole and omeprazole were compared）. Network Meta-analysis was performed by using R 3. 6. 1 and Stata 12. 0 SE software. RESULTS: Totally 15 literature were collected

including 1 255 cases of stress ulcer bleeding. Network Meta-analysis showed that in terms of clinical efficiency

there were no statistically significant differences between esomeprazole and pantoprazole（ OR = 1. 26

90% CI = 0. 46-3. 48）

pantoprazole and omeprazole（ OR = 1. 80

90% CI= 0. 66-4. 87）

esomeprazole and omeprazole（ OR = 2. 27

90% CI = 0. 80-6. 50）. In terms of total clinical efficiency

esomeprazole was not better than pantoprazole（ OR = 2. 42

90% CI = 0. 91-6. 43）

pantoprazole was superior to omeprazole（ OR = 2. 64

90% CI = 1. 01-6. 89）

and esomeprazole was better than omeprazole（ OR = 6. 39

90% CI =2. 31-17. 67）. In terms of safety

there were no statistically significant differences in the total incidence of adverse drug reactions and the incidence of headache and dizziness among esomeprazole

pantoprazole and omeprazole.CONCLUSIONS: For patients with stress ulcer bleeding

esomeprazole is not better than pantoprazole in terms of total clinical efficiency

but esomeprazole and pantoprazole are both superior to promeprazole. Yet in terms of clinical efficiency and safety

the three proton pump inhibitors are similar.