OBJECTIVE: To probe into the clinical efficacy of Wenyang Jianpi decoction in the treatment of chronic atrophic gastritis（ CAG）

and analyze its effects on pepsinogen（ PG） and oxidative stress in patients.METHODS: Totally 96 patients with CAG admitted into Suzhou Hospital of Traditional Chinese Medicine from Apr.2018 to Apr. 2019 were extracted to be divided into the study group and the control group via random number table

with 48 cases in each group. The control group was treated with conventional western medicine

and the study group received Wenyang Jianpi decoction

with 3 months of continuous treatment. The efficacy

traditional Chinese medicine symptom score

histopathological lesion score

PG Ⅰ and PG Ⅱ levels

oxidative stress indicators and inflammatory factor levels of two groups were compared. RESULTS: The total effective rate in the study group was 93. 75%（ 45/48）

significantly higher than that in the control group 68. 75%（ 33/48）

and the difference was statistically significant（ Z = 2. 803

P = 0. 004）. After treatment

the scores of all traditional Chinese medicine syndrome in the study group were significantly lower than those in the control group（ epigastric pain: t = 7. 238

P < 0. 001; epigastric distension and congestion: t = 6. 273

P < 0. 001; greasy dry mouth: t = 4. 063

P < 0. 001; poor appetite: t = 4. 676

P < 0. 001; sore body: t = 2. 087

P = 0. 040; uncomfortable stool: t = 6. 848

P < 0. 001）. The scores of all histopathological lesions in the study group were significantly lower than those in the control group（ mucosal inflammation: t = 5. 221

P < 0. 001; gland reduction or atrophy: t = 6. 049

P < 0. 001; intestinal metaplasia: t =5. 769

P < 0. 001; dysplasia: t = 3. 833

P < 0. 001）. After treatment

the levels of PGⅠ

PGⅡ and PGⅠ/PGⅡin the study group were significantly higher than those in the control group（ PGⅠ: t = 21. 446

P < 0. 001; PGⅡ:t = 2. 459

P = 0. 016; PG Ⅰ/PG Ⅱ: t = 10. 161

P < 0. 001）. The levels of superoxide dismutase（ SOD） and glutathione peroxidase（ GSH-Px） in the study group were significantly higher than those in the control group（ SOD:t = 5. 239

P < 0. 001; GSH-Px: t = 11. 414

P < 0. 001）

the level of malondialdehyde（ MDA） was significantly lower than that in the control group（ t = 5. 152

P < 0. 001）. The levels of inflammatory factors in the study group were significantly lower than those in the control group（ tumor necrosis factor α: t = 4. 141

P < 0. 001; interleukin 6:t = 5. 235

P < 0. 001; high sensitivity C-reactive protein: t = 8. 390

P < 0. 001）

the differences were statistically significant. CONCLUSIONS: Wenyang Jianpu decoction can effectively improve the pathological state of gastric mucosa in patients with CAG

regulate the levels of pepsinogen and oxidative stress

reduce the levels of inflammatory factors

and improve the clinical therapeutic effects.