OBJECTIVE: Based on the method of network pharmacology

to explore the pharmacological mechanism of Shengjiang Xiexin decoction in the treatment of colorectal cancer（ CRC）

so as to provided a basis for the application of classic prescription expansion and drug mechanisms research. METHODS: The main chemical components and targets of Shengjiang Xiexin decoction were obtained through the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform（ TCMSP）. CRC disease targets were collected by OMIM database

TTD database and GeneCards database. The protein-protein interaction（ PPI） analysis and PPI network diagram were performed by STRING platform. Metascape platform was used to conduct statistical analysis on "drugscomponents-targets"

biological processes and pathways. Finally

the Cytoscape software was adopted to establish the network of"ingredients of Shengjiang Xiexin decoction-colorectal cancer-pathway". RESULTS: The core active ingredients of Shengjiang Xiexin decoction in the treatment of CRC were baicalein

naringenin

formononetin

1-Methoxy-phaseollidin

etc; the core targets were HSP90 AA1

ESR1

AR

NOS2

etc; the main participated pathways were cancer-related pathway

CRC-related pathway

IL-17 signaling pathway

endocrine resistance pathway

apoptosis pathway

etc; the functions of Shengjiang Xiexin decoction were mainly to regulate transcription factor binding

nuclear receptor activity

transcription factor activity

steroid hormone receptor activity

protein kinase binding

etc. CONCLUSIONS: This study has preliminarily verified the action mechanism of Shengjiang Xiexin decoction in the treatment of CRC

and provided theoretical basis for its clinical application and mechanism research.