OBJECTIVE: To probe into the characteristics and regularities of adverse drug reactions（ ADR） induced by drug combination of antiviral agents（ ribavirin injection + Lopinavir/Ritonavir tablets + recombinant human interferonα2 b injection） in patients with COVID-19

so as to promote rational medication. METHODS: Retrospective analysis was adopted to collect and analyze the ADR occurred during the treatment of drug combination of antiviral agents in 7 patients with COVID admitted into the Affiliated Hospital of Gansu Medical College. RESULTS: Of the 7 patients with COVID-19

6 had bilirubin increase

5 had diarrhea

4 had appetite decrease

1 had mild abnormal liver function and 1 had dizziness. Symptoms of bilirubin increase

appetite decrease

mild abnormal liver function and dizziness gradually disappeared after drug withdrawal

three patients with severe diarrhea turned better after receiving Live combined bifidobacterium enteric-coated capsules. The average appearance time of bilirubin increase was 3. 50 ± 1. 05 days after treatment

and the appearance time of diarrhea was 2 days after treatment. CONCLUSIONS: Clinical pharmacists and physicians in medical institutions should pay more attention to and summarize the content of rational drug application

so as to provide reference for the revision of the "New Coronavirus Pneumonia Diagnosis and Treatment Scheme".