OBJECTIVE: To conduct a cross-sectional study on the application of Chinese patent medicine in immunosuppressive maintenance therapy on patients underwent single-center lung transplantation

to probe into the characteristics of clinical application of Chinese patent medicine

so as to provide references for rational application of Chinese patent medicine. METHODS: Postoperative medication information of patients undergoing lung transplant admitted into the China-Japan Friendship Hospital from Mar. 2017 to Aug. 2019

SAS 9. 4 was adopted to analyze related data. RESULTS: Among the 166 patients underwent lung transplantation

104 patients had used Chinese patent medicine

accounted for 62. 65%. 25 categories of Chinese patent medicine were involved in postoperative immunosuppressive maintenance therapy in patients underwent lung transplantation

including diaphoretic prescription

purgative prescription

qi-regulating prescription

heat-clearing prescription

stasis-removing prescription

phlegmresolving and cough and asthma relieving prescription

body-strengthen prescriptions and tranquillizer prescriptions

the top 3 Chinese patent medicine ranked by case load were respectively Bailing capsule

Jinhua Qinggan granule and Niaoduqing granule. Of the 104 patients used Chinese patent medicine after surgery

34 patients（ 32. 69%） had been applied 2 or above drug combination. The irrational application of Chinese patent medicine mainly including no TCM diagnosis

repeated dose and over-dose. In the immunosuppressive maintenance therapy after lung transplantation

the difference in blood concentration of tacrolimus between patients using and not using Chinese patent medicine was statistically significant（ P < 0. 000 1）. CONCLUSIONS: The rationality of therapeutic regimen of Chinese patent medicine should be considered in the immunosuppressive maintenance therapy after lung transplantation

the principle of syndrome differentiation with disease differentiation should be followed

and pharmaceutical care should be paid attention to ensure the rationality of clinical medication.