OBJECTIVE: To probe into the effect of octreotide combined with continuous renal replacement therapy（ CRRT） on the expression of serum M30 and M65 in patients with acute severe pancreatitis. METHODS: Totally 126 patients with acute severe pancreatitis admitted into the emergency department of the Third Hospital of Xingtai City from Feb. 2016 to Apr. 2019 were selected and divided into control group and observation group via random number table. The control group was given conventional therapy combined with CRRT

while the observation group was treated with octreotide acetate injection based on the control group. Differences in immune globulin

endotoxin

inflammatory factor

biochemical criterion

serum M30 and M50 levels were compared between two groups at 2 weeks after treatment. RESULTS: At 2 weeks after treatment

the total effective rate of observation group was 90. 48%（ 57/63）

which was significantly higher than that of the control group（ 68. 25%

43/63）

with statistically significant difference（ P < 0. 05）. At 2 weeks after treatment

the serum endotoxin

inflammatory factor（ C reaction protein

interleukin 6 and tumor necrosis factor α）

biochemical criterion（ serum amylase

glycolytic enzyme）

serum M30 and M65 levels of both groups had been significantly decreased

and those of the observation group were significantly lower than the control group

with statistically significant differences（ P < 0. 05）; while the immune globulin（ IgM

IgA and IgG）and inflammatory factor（ interleukin 10） levels of both groups had been significantly increased

the IgM

IgG and IL-10 levels of observation group were significantly higher than those of the control group

with statistically significant differences（ P < 0. 05）. CONCLUSIONS: The combination of octreotide and CRRT can significantly reduce the expression of serum M30 and M65 in patients with acute severe pancreatitis

relieve inflammatory reaction

protect pancreatic tissue

with remarkable therapeutic effect.