OBJECTIVE: To probe into the clinical effect of Huazhuo Kangxian Baogan decoction in the treatment of chronic hepatitis B（ CHB） liver fibrosis. METHODS: Totally 108 patients with CHB liver fibrosis admitted to the Fourth People’s Hospital of Huai’an from Sept. 2018 to Sept. 2019 were selected and divided into control group（ 54 cases

treated with recombinant human interferon α2 b） and research group（ 54 cases

given Huazhuo Kangxian Baogan decoction combined with recombinant human interferon α2 b） via random number table

both groups were treated for 3 months. Differences in clinical efficacy

liver function indicator

liver fibrosis indicator

histological score

immune function indicator and incidences of adverse drug reactions were compared between two groups. RESULTS: The clinical total effective rate of research group was 88. 89%（ 48/54）

which was significantly higher than that of the control group（ 74. 07%

40/54）

with statistically significant difference（ P <0. 05）. After treatment

the aspartate aminotransferase

alanine aminotransferase

total bilirubin

laminin

hyaluronic acid and type-Ⅳ collagen levels of research group were significantly lower than those of the control group; the degree of liver fibrosis and score of inflammation activity of research group were significantly lower than those of the control group; the CD8+of research group was significantly lower than that of the control group

while the nature killer cell

CD4+and CD4+/CD8 levels were significantly higher than those of the control group

with statistically significant differences（ P < 0. 05）. During treatment

the incidences of adverse drug reactions of control group and research group were respectively 14. 81%（ 8/54） and 9. 26%（ 5/54）

the difference had no statistical significance（ χ2= 0. 787

P = 0. 375）. CONCLUSIONS: Huazhuo Kangxian Baogan decoction has good clinical efficacy in the treatment of CHB liver fibrosis

which can improve liver function and severity of fibrosis

reduce liver inflammation

promote immune function

with high safety.