尼可地尔联合依那普利叶酸片用于急性ST段抬高型心肌梗死患者急诊经皮冠状动脉介入术后的疗效观察

牟丽娜; 张俊岭; 王丽; 刘艳洁; 吕文浩; 付建平

doi:10.14009/j.issn.1672-2124.2020.10.009

您当前的位置：

首页 >

文章列表页 >

尼可地尔联合依那普利叶酸片用于急性ST段抬高型心肌梗死患者急诊经皮冠状动脉介入术后的疗效观察

论著 | 更新时间：2022-10-08

- 尼可地尔联合依那普利叶酸片用于急性ST段抬高型心肌梗死患者急诊经皮冠状动脉介入术后的疗效观察
- Observation on Efficacy of Nicorandil Combined with Enalaprilat Folic Acid Tablets in Patients with Acute ST-segment Elevation Myocardial Infarction After Emergency Percutaneous Coronary Intervention
- 中国医院用药评价与分析 2020年20卷第10期页码：1185-1188
- 作者机构：
  
  1. 哈励逊国际和平医院心内科
  2. 衡水市第四人民医院心内科
- 作者简介：
- 基金信息：
  
  河北省2014年度医学科学研究重点课题计划（No.ZD20140474）
- DOI：10.14009/j.issn.1672-2124.2020.10.009
  中图分类号： R542.22
- 纸质出版日期：2020，
扫描看全文
[1]牟丽娜,张俊岭,王丽,刘艳洁,吕文浩,付建平.尼可地尔联合依那普利叶酸片用于急性ST段抬高型心肌梗死患者急诊经皮冠状动脉介入术后的疗效观察[J].中国医院用药评价与分析,2020,20(10):1185-1188+1192.

MU Lina, ZHANG Junling, WANG Li, et al. Observation on Efficacy of Nicorandil Combined with Enalaprilat Folic Acid Tablets in Patients with Acute ST-segment Elevation Myocardial Infarction After Emergency Percutaneous Coronary Intervention[J]. 2020,20(10):1185-1188.
[1]牟丽娜,张俊岭,王丽,刘艳洁,吕文浩,付建平.尼可地尔联合依那普利叶酸片用于急性ST段抬高型心肌梗死患者急诊经皮冠状动脉介入术后的疗效观察[J].中国医院用药评价与分析,2020,20(10):1185-1188+1192. DOI： 10.14009/j.issn.1672-2124.2020.10.009.

MU Lina, ZHANG Junling, WANG Li, et al. Observation on Efficacy of Nicorandil Combined with Enalaprilat Folic Acid Tablets in Patients with Acute ST-segment Elevation Myocardial Infarction After Emergency Percutaneous Coronary Intervention[J]. 2020,20(10):1185-1188. DOI： 10.14009/j.issn.1672-2124.2020.10.009.

摘要

目的:探讨尼可地尔联合依那普利叶酸片对急性ST段抬高型心肌梗死（ST-segment elevation myocardial infarction

STEMI）患者急诊经皮冠状动脉介入术（percutaneous coronary intervention

PCI）后心肌损伤、同型半胱氨酸（Hcy）及预后的影响。方法:选取2018年2月至2019年10月于哈励逊国际和平医院住院的STEMI患者300例

采用随机数字表法分为A、B及C组

每组100例。A组患者给予依那普利片10 mg

1日1次

口服; B组患者给予依那普利叶酸片10. 8 mg

1日1次

口服; C组患者给予尼可地尔5 mg

1日3次+依那普利叶酸片10. 8 mg

1日1次

口服。三组患者均行急诊PCI治疗

观察3个月。检测三组患者PCI术前及PCI术后血清肌钙蛋白Ⅰ（c TnⅠ）、Hcy水平

对比心电图变化

记录3个月内主要心脏不良事件发生情况、再住院率。结果:B组、C组患者PCI术后3、7及10 d的c TnⅠ水平明显低于A组

C组患者PCI术后10 d的c TnⅠ水平明显低于B组; C组患者PCI术后7、10 d心电图相关导联抬高ST段回落> 50%峰值的发生率高于A组、B组

差异均有统计学意义（P <0. 05）。B组、C组患者治疗4、8及12周后的Hcy水平明显低于A组

C组患者治疗8、12周后的Hcy水平明显低于B组

差异均有统计学意义（P <0. 05）。C组患者再住院率及再发心绞痛的发生率明显低于A组、B组

差异均有统计学意义（P <0. 05）。结论:尼可地尔联合依那普利叶酸片能够减轻心肌损伤

降低Hcy水平

降低STEMI患者急诊PCI术后3个月内的主要心脏不良事件发生率

改善预后。

Abstract

OBJECTIVE: To probe into the effect of nicorandil combined with Enalaprilat folic acid tablets on myocardial damage

homocysteine and prognosis in patients with acute ST-segment elevation myocardial infarction（ STEMI） after emergency percutaneous coronary intervention（ PCI）. METHODS: Totally 300 patients with STEMI admitted into Harrison International Peace Hospital from Feb. 2018 to Oct. 2019 were selected and randomly divided into group A

group B and group C

with 100 cases in each. The group A was treated with 10 mg of Enalaprilat tablets orally for once a day; group B was treated with 10. 8 mg of Enalaprilat folic acid tablets orally for once a day; group C was given 5 mg of nicorandil for three times a day combined with 10. 8 mg of Enalaprilat folic acid tablets for once a day. All three groups were given emergency PCI and observed for 3 months. The c TnⅠand Hcy levels of three groups before and after PCI were detected

changes of electrocardiogram were compared

major adverse cardiac events and rehospitalization rates within 3 months were recorded. RESULTS: The cTn Ⅰ levels of group B and group C were significantly lower than those of group A at 3

and 10 days after PCI

and the cTn Ⅰ level of group C was significantly lower than that of group B at 10 days after PCI; the incidence of ST-segment fall > 50% peak in ECG-related leads of group C was higher than that of group A and group B at 7 and 10 days after PCI

with statistically significant differences（ P < 0. 05）. The Hcy levels of group B and group C were significantly lower than those of group A at 4

8 and 12 weeks after treatment

the Hcy level of group C was significantly lower than that of group B at 8 and 12 weeks after treatment

with statistically significant differences（ P < 0. 05）. The incidences of rehospitalization and recurrence of anginal of group C were significantly lower than those of group A and group B

with statistically significant differences（ P < 0. 05）. CONCLUSIONS:The combination of nicorandil and Enalaprilat folic acid tablets can relieve myocardial damage

reduce Hcy level

reduce the incidence of major adverse cardiac events in STEMI patients within 3 months after emergency PCI

and improve prognosis.

关键词

尼可地尔依那普利叶酸片急性ST段抬高型心肌梗死心肌损伤同型半胱氨酸

Keywords

NicorandilEnalaprilat folic acid tabletsAcute ST-segment elevation myocardial infarctionMyocardial damageHomocysteine

references

查看原文

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

尼可地尔联合氯吡格雷对急性冠脉综合征患者PCI术后血小板活化指标及血清BNP、MMP-9的影响

银杏叶胶囊联合前列地尔注射液对后循环缺血性眩晕患者脑血流和血清同型半胱氨酸、成纤维细胞生长因子21的影响

重组人脑利钠肽联合尼可地尔对缺血性心力衰竭患者心脏功能及血清一氧化氮、内皮素水平的影响

尼莫地平联合神经内镜微创术治疗高血压脑出血的效果及对血清同型半胱氨酸、白细胞介素1β的影响

血清同型半胱氨酸、肿瘤标志物与转移性结直肠癌患者化疗疗效的相关性研究