OBJECTIVE: To probe into the clinical efficacy of Tongxinluo capsule combined with recombinant human brain natriuretic peptide for injection in the treatment of patients with acute exacerbation of chronic pulmonary heart disease

and to analyze its effect on cardio-pulmonary function and hemorheology. METHODS: Totally 86 patients with acute exacerbation of chronic pulmonary heart disease admitted into Xintai Hospital of Traditional Chinese Medicine from Aug. 2016 to Oct. 2018 were selected and divided into control group（ 43 cases） and research group（ 43 cases） via random number table. Both groups were given conventional therapy

of which the control group was treated with recombinant human brain natriuretic peptide for injection

while the research group was given Tongxinluo capsule based on the control group. Differences in clinical efficacy

cardio-pulmonary function indicator

serological indicator

hemorrheological indicator and incidences of adverse drug reactions were compared between two groups.RESULTS: The clinical total effective rate of research group was 88. 37%（ 38/43）

which was significantly higher than that of the control group（ 69. 77%

30/43）

with statistically significant difference（ P < 0. 05）. After treatment

the thickness of anterior wall of right ventricle

the end-diastolic diameter of right ventricle and the systolic pressure of pulmonary artery of research group were significantly lower than those of the control group; the forced vital capacity

forced expiratory volume in 1 s（ FEV1） and FEV1/forced vital capacity（ FVC） of research group were significantly higher than those of the control group; the copeptin

5-hydroxytryptamine and angiopoietin Ⅱ levels of research group were significantly lower than those of the control group; the plasma viscosity

whole blood low-viscosity

whole blood high-viscosity

fibrinogen and hematocrit levels of research group were significantly lower than those of the control group

with statistically significant differences（ P < 0. 05）. No severe adverse drug reactions occurred in both groups during treatment. CONCLUSIONS: The clinical efficacy of Tongxinluo capsule combined with recombinant human brain natriuretic peptide for injection in the treatment of patients with acute exacerbation of chronic pulmonary heart disease is remarkable

which can improve patients’ cadio-pulmonary function

reduce blood viscosity

with high safety.