OBJECTIVE: To probe into the efficacy of tranexamic acid in the treatment of seborrheic keratosis and its effects on patients’ quality of life. METHODS: Totally 80 patients with seborrheic keratosis in the First Affiliated Hospital of Air Force Medical University of PLA from Jun. 2017 to Sept. 2019 were selected and divided into research group and control group via random number table

with 40 cases in each group. The control group was given conventional therapy

while the research group was treated with tranexamic acid. The clinical efficacy

safety and life quality scores of both groups were compared. RESULTS: The total effective rate of research group was 97. 50%（ 39/40）

which was significantly higher than that of the control group（ 85. 00%

34/40）

with statistically significant difference（ P < 0. 05）. The incidences of swelling

causalgia

nausea

vomiting and diarrhea of research group were not statistically different compared with the control group（ P > 0. 05）. After treatment

the scores of social contact

symptoms（ causalgia）

housework

mental feelings（ depression

etc.）

clothing

physical activities

work and study

sleep and interpersonal relationship in two groups were statistically significant compared with those before treatment and between two groups（ P < 0. 05）. CONCLUSIONS: The efficacy of tranexamic acid in the treatment of seborrheic keratosis is remarkable

which has important clinical reference value for early risk assessment and prognosis of patients

with higher safety.