OBJECTIVE: By participating into the establishment of standardized treatment ward for chemotherapy induced nausea and vomiting （CINV）

to explore the role of clinical pharmacists in the standardized management of CINV under the collobaorative drug therapy management （CDTM） work model. METHODS: In Aug. 2019

Fujian Provincial Hospital （hereinafter referred to as "our hospital "） established the working mode of non-nausea and vomiting management for patients with CDTM chemotherapy led by clinical pharmacists. A clinical pharmacist-led CINV was constructed and patients receiving chemotherapy for the first time was managed in an all-round way.Pharmacist participates in the treatment of CINV by establishing archives and individualized antiemetic programs

pharmacological monitoring and medication education. Information of patients in the department of oncology of our hospital from Jun. to Dec. 2019 were collected

and the occurrence of CINV in cancer chemotherapy patients were compared before and after the implementation of the CDTM model. RESULTS: A total of 130 newly diagnosed patients with the first chemotherapy were enrolled

including 34 patients before the implementation of CDTM model （from Jun.to Jul. 2019） and 96 patients after the implementation of CDTM model （from Aug. to Dec. 2019）. Compared with before the implementation of CDTM model

after the application of CDTM model by clinical pharmacists

the overall incidence and severity of CINV in patients decreased significantly

and the difference was statistically significant （P<0. 05）

in particular

the incidence of CINV in patients with high and moderate risk of emetogenesis decreased significantly. In addition

the functional vomiting life index of the patients increased significantly

and the difference was statistically significant （P < 0. 05）. CONCLUSIONS: Clinical pharmacists can play an active role in the standardized treatment of CINV through the CDTM work model

which is worthy of promotion.