OBJECTIVE: To investigate the adverse drug reactions （ADR） and drug interaction of tacrolimus

so as to provide reference for the rational clinical use of drugs. METHODS: CNKI

CBM and Wanfang database were retrieved from Jan. 2000 to Jan. 2020

and case reports on tacrolimus-induced ADR and drug interaction were collected for statistical analysis. RESULTS: A total of 44 articles on ADR induced by tacrolimus were retrieved

including 69 patients. There were 20 literature on drug interaction

including 36 patients. A total of 105 patients met the diagnostic criteria for ADR. Among the 105 patients

75 cases were organ transplant

accounting for 71. 4%; a total of 80 patients （76. 2%） developed ADR within 3 months; there was 1 death. ADR involved organs and （or） system in 116 casetimes

mainly for blood system

totally 62 case-times

accounting for 53. 4%. Drugs used in combination with tacrolimus mainly included antifungal drugs

calcium channel blockers

berbamine hydrochloride and Wu Zhi capsules.CONCLUSIONS: The occurrence of ADR induced by tacrolimus is related to factors such as drug combination

patients’ metabolic capacity and blood drug concentration

and the individual differences are significant. Therefore

clinical attention should be paid to closely observe the occurrence of ADR in patients after administration and timely treatment should be given.