OBJECTIVE: To evaluate the clinical efficacy of Xingnaojing injection in the auxiliary treatment of consciousness disturbance induced by systemic diseases

so as to provide evidence-based references for clinical practice. METHODS: The Cochrane Library

Pub Med

Wanfang

CNKI and Sinomed databases were systematically retrieved to collect systematic review/meta-analysis of Xingnaojing injection in the treatment of consciousness disturbance. After two reviewers screened the literature according to the inclusion and exclusion criteria

extracted the data and evaluated the quality

the evidence was comprehensively analyzed. RESULTS: A total of 5 literature were included

all of which were systematic review/meta-analysis

with medium overall quality. In the treatment of consciousness disturbance induced by carbon monoxide poisoning

hepatic encephalopathy

alcoholism and pulmonary encephalopathy

compared with conventional treatment alone

the combined application of Xingnaojing injection can significantly increase the effective rate of treatment and shorten the recovery time of poisoned patients

shorten the disappearance time of symptoms of alcoholism patients and improve the arterial partial pressure of oxygen and carbon dioxide

the differences were statistically significant（ P < 0. 05）. CONCLUSIONS: Xingnaojing injection in the auxiliary treatment of consciousness disturbance induced by systemic diseases can further improve the clinical efficacy.However

further clinical studies should be performed to clarify the safety profiles and comparative effectiveness among other active comparators.