OBJECTIVE: To probe into the clinical effects of ginkgolides sodium chloride injection combined with butylphthalide in the treatment of acute progressive stroke. METHODS: Totally 82 patients with acute progressive stroke admitted into neurology department of Lianyungang Hospital Affiliated to Nanjing University of Chinese Medicine from Oct. 2017 to Sept. 2019 were extracted to be divided into the control group and the observation group via the random number table

with 41 cases in each group. The control group was given butylphthalide

while the observation group additionally received ginkgolides sodium chloride injection based on the control group. The clinical efficacy

differences of neurological improvement [National Institutes of Health Stroke Scale （NIHSS） score ]

coagulation function indicators [fibrinogen （FIB）

prothrombin time （PT） and thrombin time （TT） ] levels

homocysteine （HCY） and D-dimer levels before and after treatment were compared. Patients were followed up for two months to evaluate the prognosis. RESULTS: Before treatment

there was no significant difference in NIHSS score

coagulation function indicators

HCY and D-dimer levels between two groups （P>0. 05）. After treatment

the NIHSS score in the observation group was significantly lower than that in the control group

and the difference was statistically significant （P<0. 05）.The total effective rate of the observation group was 90. 24% （37/41）

significantly higher than that of the control group 73. 17% （30/41）

and the difference was statistically significant （P<0. 05）. After treatment

the level of FIB in the observation group was significantly higher than that in the control group

and the levels of PT and TT were significantly shorter than those in the control group

the difference was statistically significant （P<0. 05）. After treatment

the levels of HCY and D-dimer in the observation group were significantly lower than those in the control group

and the differences were statistically significant （P < 0. 05）. The good prognosis rate of patients in the observation group was 75. 61% （31/41）

significantly higher than that of the control group 53. 66% （22/41）

and the difference was statistically significant （P<0. 05）. CONCLUSIONS: Ginkgolides sodium chloride injection combined with butylphthalide is effective in the treatment of acute progressive stroke

which can reducing the neurological injury and improving the prognosis.