OBJECTIVE: To probe into the efficacy of ulinastatin combined with imipenem in the treatment of acute respiratory distress syndrome induced by sepsis and its effect on leukocyte-platelet aggregate level and cardiac function. METHODS: Totally 130 patients with acute respiratory distress syndrome induced by sepsis admitted into ICU of the Third People’s Hospital of Hainan Province from Sept. 2015 to Jun. 2019 were selected and divided into control group and research group via the random number table

with 65 cases in each group. The research group was given ulinastatin combined with imipenem

while the control group was treated with ulinastatin alone. The white blood cell （WBC） count

C-reactive protein （CRP）

arterial partial pressure of oxygen （PaO

2

）

partial pressure of carbon dioxide in artery （PaCO

2

） and oxygenation index （PaO

2

/FiO

2

） of both groups were observed

acute physiology and chronic health evaluation （APACHEⅡ） system was adopted to grade the health condition of both groups before and after treatment

differences in leukocyte-platelet aggregation

changes of cardiac function

success rate of ventilator withdrawal

fatality rate and hospital stay between two groups were compared. RESULTS: Compared with before treatment

the WBC count in peripheral blood

serum CRP

PCT and APACHE Ⅱ scores of both groups were significantly decreased after treatment

and those of the research group were significantly lower

with statistically significant differences （P

<

0. 05）; compared with before treatment

the PaO

2

and PaO

2

/FiO

2

levels of both groups increased significantly

while the PaCO

2

level decreased significantly

and the amplitude of variation in research group was larger

with statistically significant differences （P

<

0. 05）. After treatment

the platelet-neutrophil aggregation and leukocyte-platelet aggregation levels of both groups decreased significantly

and those of the research group were significantly lower

with statistically significant differences （P

<

0. 05）. After treatment

the LVEDD levels of both groups were significantly lower than those of before treatment

while the LVEF levels increased significantly

and the amplitude of variation in research group was larger

with statistically significant differences （P

<

0. 05）. The ICU fatality rate of research group was significantly lower than that of the control group

the ICU hospital stay and ventilator withdrawal time were significantly shorter than those of the control group

and the success rate of ventilator withdrawal was significantly higher than that of the control group

with statistically significant differences （P

<

0. 05）.CONCLUSIONS: The efficacy of ulinastatin combined with imipenem in the treatment of acute respiratory distress syndrome induced by sepsis is remarkable.