OBJECTIVE: To probe into the clinical efficacy of Resina draconis tablets combined with flurbiprofen cataplasm in the treatment of acute soft tissue contusion and its effects on oxidative stress. METHODS: Totally 88 patients with acute soft tissue contusion admitted into Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine from Mar. 2014 to Dec. 2018 were extracted to be divided into the control group and the observation group via the random number table

with 44 cases in each group. Both groups were treated with routine treatment

the control group was given flurbiprofen cataplasm

while the observation group additionally received Resina draconis tablets on the basis of the control group. The treatment effects

adverse drug reactions

changes of symptom scores and oxidative stress indicators [malondialdehyde （MDA）

nitric oxide （NO） and superoxide dismutase （SOD） ] before treatment and 5 d after treatment in two groups were observed. RESULTS: The total effective rate in the observation group was95. 45% （42/44）

significantly higher than that in the control group 88. 64% （36/44）

and the difference was statistically significant （P < 0. 05）. After 5 d of treatment

the scores of swelling

pain and ecchymosis in the observation group were significantly lower than those in the control group during the same period

and the differences were statistically significant （P< 0. 05）. After 5 d of treatment

the levels of MDA

NO and SOD in the observation group were significantly better than those in the control group during the same period

and the differences were statistically significant （P < 0. 05）. The incidence of adverse drug reactions in the observation group was 9. 09% （4/44）

compared with 6. 82% （3/44） in the control group

the difference was not statistically significant （P >0. 05）. CONCLUSIONS: The efficacy of Resina draconis tablets combined with flurbiprofen cataplasm in the treatment of acute soft tissue contusion is significant

which can effectively improve the symptoms and reduce the levels of oxidative stress with higher safety.