OBJECTIVE: To probe into the efficacy of eucalyptol limonene and pinene combined with azithromycin in the treatment of chronic rhinosinusitis in children and its effect on immune globulin E （IgE） and Toll-like receptor-4 （TLR4） levels. METHODS: Totally 96 children with chronic rhinosinusitis admitted into our hospital from Mar. 2017 to Mar. 2019 were selected and divided into combined group and azithromycin group via random number table

with 48 cases in each group. The azithromycin group was treated with Azithromycin granules

the combined group was given Eucalyptol limonene and pinene enteric-coated soft capsule based on the azithromycin group. The IgE and TLR4 levels of both groups were detected

scores of clinical symptom

pain and Lund-Kennedy nasal endoscopy scores were evaluated

clinical efficacy

incidences of recurrence and adverse drug reactions were collected. RESULTS: The IgE and TLR4 levels of combined group after treatment were significantly lower than those of azithromycin group

with statistically significant differences （P < 0. 05）. Symptom （nose

sleep disorders

emotion

related symptoms and sign） scores of combined group after treatment were significantly lower than those of azithromycin group

with statistically significant differences （P<0. 05）. The pain score and Lund-Kennedy nasal endoscopy score of combined group after treatment were significantly lower than those of azithromycin group

with statistically significant differences （P < 0. 05）. The total effective rate of combined group was significantly higher than azithromycin group

while the incidence of recurrence was significantly lower

with statistically significant differences （P < 0. 05）. CONCLUSIONS: The efficacy of eucalyptol limonene and pinene combined with azithromycin in the treatment of chronic rhinosinusitis in children is remarkable

which can significantly reduce IgE and TLR4 levels

improve clinical symptoms

relieve pain and promote recovery.