OBJECTIVE: To probe into the drug resistance

risk factors and efficacy of drug combination of fluoroquinolones in patients with pulmonary tuberculosis. METHODS: Totally 130 patients with pulmonary tuberculosis admitted into Haikou Hospital Affiliated to Xiangya School of Medicine of CSU from Jan. 2017 to Jan. 2019 were selected and divided into initial resistance group （60 cases） and acquired resistance group （70 cases） according to whether they had undergone anti-tuberculosis treatment and the resistance of tuberculosis bacteria to anti-tuberculosis drugs

drug resistance of tuberculosis patients was analyzed through drug susceptibility test

meanwhile

Logistic analysis was adopted to analyze the risk factors of drug resistance. At the same time

all the 130 patients were divided into observation group and control group via random number table

with 65 cases in each group; the control group was given antitubercular agent

while the observation group was given levofloxacin based on the control group; the negative conversion ratio of sputum bacterium

lesion

cavity and comprehensive efficacy of both groups were observed.RESULTS: The single drug resistance and multi drug resistance rates of initial resistance group were significantly lower than those of the acquired resistance group

with statistically significant differences （P < 0. 05）. The drug resistance rates of patients in acquired resistance group to streptomycin and rifampicin were significantly higher than those of initial resistance group

with statistically significant differences （P < 0. 05）. Results of multifactor logistic regression analysis indicated family income

number of treatment

smoking history and drug combination were the risk factors that affected the drug resistance of tuberculosis patients. At 12 months and 18 months after treatment

the negative conversion rate of sputum bacterium of observation group was significantly higher than that of the control group; at 18 months after treatment

the lesion absorption rate

cavity reduction rate and total effective rate of observation group were significantly higher than those of the control group

with statistically significant differences （P < 0. 05）.CONCLUSIONS: Timely drug susceptibility testing for tuberculosis patients

formulating rationalized treatment plan and conducting regular treatment for patients to prevent the production of drug-resistant bacteria

the drug combination of fluoroquinolones can reduce the positive rate of Mycobacterium tuberculosis in sputum

reduce cavity and improve efficacy for patients.