OBJECTIVE:To investigate the overdose using of Amlodipine besylate tablets on inpatients in a certain grade III level A hospital（hereinafter referred to as "this hospital"）

so as to provide references for clinical rational medication.METHODS:From 2017 to 2019

among the 6 908 inpatients treated with Amlodipine besylate tablets in this hospital

patients with daily doses > 10 mg were screened out and classified by clinical departments and major diseases

the safety and effectiveness of overdose medications were analyzed.RESULTS:Among the 6 908 patients extracted

105 were overdosed with Amlodipine besylate tablets

all the cases occurred in nephrology department and patients with chronic kidney disease

and the daily dose of overdose medication ranged from 12.5 mg to 30 mg.Among the 105 patients who were treated with Amlodipine besylate tablets at an overdose medication

there were 4 cases of adverse drug reaction

with the incidence was 3.8%

all of which were mild and did not cause severe adverse consequences;29 patients were excluded from effectiveness analysis

the remaining 76 patients had significantly lower blood pressure after overdose of Amlodipine besylate tablets.CONCLUSIONS:The people in this hospital who are given overdose of Amlodipine besylate tablets（daily dose from 12.5 to 30 mg） are patients with chronic kidney disease

most patients can significantly reduce systolic and diastolic blood pressure after increasing the dose

with good safety.