OBJECTIVE:To evaluate the efficacy

safety and economy of calcitriol in the prevention and treatment of osteoporosis by rapid health technology evaluation.METHODS:PubMed

EMBase

the Cochrane Library

CNKI

SinoMed

Wangfang database and HTA related websites and databases were systematically retrieved to extract the data according to the inclusion and exclusion criteria

and quality evaluation and qualitative analysis of literature were evaluated.RESULTS:A total of 8 literature were included

including 7 systematic reviews and meta-analysis（Metaanalysis）

and 1 economic research.Calcitriol monotherapy can improve the bone density of patients

significantly decreasing the levels of bone turnover markers

and reduce the risks of falling.Calcitriol combined with bisphosphonate therapy can improve the symptoms of bone pain

and the combination of calcitriol and calcium can improve the muscle strength of patients.However

no consistent conclusion had been reached regarding the reduction of fracture risk with calcitriol monotherapy or in combination with other drugs.Common adverse drug reactions of calcitriol were hypercalcemia and hypercalciuria

but the degree was relatively mild.Compared with alfacalcidol monotherapy

calcitriol monotherapy was inferior and uneconomical.Compared wit alfacalcidol combined with calcium regimen

calcitriol combined with calcium regimen was more effective in preventing osteoporotic fractures

but its cost was also higher.CONCLUSIONS:Calcitriol monotherapy is effective in improving the bone density of patients

decreasing the levels of bone turnover markers and reducing the risk of falling.Calcitriol combined with other drugs can improve the symptoms of bone pain and muscle strength.However

no consistent conclusion have been reached regarding the reduction of fracture risk with calcitriol monotherapy or in combination with other drugs.The safety of osteotriols is good

yet the economic evaluation needs more in-depth study.