OBJECTIVE:To investigate the efficacy of aripiprazole in the treatment of amesulfoprim-induced hyperprolactinemia and range of the best effective blood drug concentration.METHODS:A total of 88 patients with schizophrenia admitted into Shunde Wu Zhong Pei Hospital in 2019 were extracted to be divided into the amisulpride group（treated with amisulpride） and combination group（treated with aripiprazole + amisulpride） via the random number table.Positive and negative syndrome scale（PANSS） score

estradiol（E2） level of two groups were observed before and after treatment

differences of the levels of prolactin（PRL） of two groups were compared before and after treatment before and after treatment.RESULTS:After treatment of 12 weeks

the PANSS scores of the combination group and the amisulpride group were respectively（69.88±7.393） and（69.77±8.815） scores

and the difference was not statistically significant（P>0.05）.The levels of E2 in the combination group and the amisulpride group were respectively（325.94±107.721） and（346.03±125.826） pmol/L

and the difference was not statistically significant（P>0.05）.The serum level of PRL in the combination group was（15.17±20.165） ng/ml

significantly lower than that of the amisulpride group（110.40±31.224） ng/ml

the difference was statistically significant（P<0.05）.After treatment of 12 weeks

the blood concentration of aripiprazole in the combination group was（236.97±99.227） ng/ml.CONCLUSIONS:Aripiprazole can effectively reduce the increase of prolactin induced by amisulpride

and the curative effect is clear

the best effective blood concentration of aripiprazole is from 150 to 350 ng/ml.