OBJECTIVE:To probe into the effects of milrinone on pulmonary oxygen function and pulmonary circulation dynamics in neonates.METHODS:Totally 100 newborn hospitalized children with pulmonary hypertension admitted into the Department of Neonatology

Baoding the First Central Hospital from Oct.2017 to Dec.2018 were extracted to be divided into the observation group and the control group via the random number table

with 50 cases in each group.The control group was treated with routine drug therapy and ventilator support

and the observation group received milrinone based on the control group.Pressure difference between the two major vessels（ΔP）

pulmonary circulation blood flow/systemic circulation blood flow（QP/QS）

stroke index（SI）

cardiac index（CI）

left ventricular ejection fraction（LVEF）

left ventricular short axis reduced rate（LVFS）

mitral valve and A E peak ratio（E/A）

oxygenation function（OI）

pulmonary artery pressure and total pulmonary resistance

aortic blood oxygen saturation level and adverse drug reactions of two groups were compared.RESULTS:After treatment

the indexes ofΔP

SI and CI in the observation group were significantly higher than those in the control group

QP/QS was significantly lower than that in the control group

with statistically significant difference（P <0.05）.After treatment

the LVEF

LVFS

E/A and OI of two groups had been improved in different degrees

and the LVEF

LVFS

E/A and OI in the observation group were significantly higher than those in the control group

with statistically significant differences（P < 0.05）.Compared with before treatment

the pulmonary artery pressure and pulmonary resistance decreased in varying degrees

and the aortic oxygen saturation increased;after treatment

the pulmonary artery pressure

pulmonary resistance and aorta oxygen saturation were significantly better in the observation group than in the control group

the differences were statistically significant（P<0.05）.CONCLUSIONS:Conventional therapy such as mechanical ventilation combined with milrinone therapy in the treatment of persistent pulmonary hypertension can improve the heart function and the oxygenation function of children

and increase the power of pulmonary circulation.