OBJECTIVE:To probe into the effects of vitamin D supplementation on wound healing

glucose metabolism

inflammation and oxidative stress in patients with diabetic foot ulcer（DFU）.METHODS:186 patients with DFU admitted into Dongying People’s Hospital from Aug.2018 to Jul.2019 were selected and divided into vitamin D group（93 cases） and control group（93 cases） via random number table.The vitamin D group was treated with Vitamin D drops orally

2 000 IU each time and twice a day for continuous 12 weeks;while the control group was given placebo.Levels of 25-hydroxyl vitamin D

3

[25（OH）D

3

]

ulcer

glycometabolism

insulin

inflammation

oxidative stress and blood lip were detected and compared between before treatment and after 12-week treatment

so as to evaluate the effects of vitamin D supplementation on the above indicators in patients with DFU.RESULTS:After 12-week treatment

the 25（OH）D

3

level of vitamin D group was significantly higher than that of the control group[（28.11±12.59） ng/ml vs.（18.47±8.55） ng/ml]

with statistically significant difference（t= 5.794

P

<

0.001）.After 12-week treatment

compared with the control group

the wound area of patients with DFU was significantly reduced

the depth of the wound was significantly shallower and the wound score was significantly reduced in vitamin D group;fasting blood glucose

glycosylated hemoglobin

insulin

homeostasis model insulin resistance index and homeostasis model insulin secretion index were significantly reduced steady-state

and its quantitative insulin sensitivity index was significantly increased

with statistically significant differences（P

<

0.05）.Inflammatory and oxidative stress indicators of high-sensitivity C-reactive protein

erythrocyte sedimentation rate

chemokines-5 and malonaldehyde of vitamin D group were significantly lower than those of the control group

with statistically significant differences（P

<

0.05）.CONCLUSIONS:Vitamin D supplementation in patients with DFU can significantly improve wound and accelerate the growth of wound tissue during DFU recovery;which can significantly improve glucose homeostasis and blood lipid

inhibit inflammation and reduce oxidative stress.